Apptio said it raised a $45 million Series E round of funding led by Janus Capital, the Hillman Company and an unnamed institutional investor. The round was joined by existing investors Andreessen Horowitz, Greylock Partners, Madrona Venture Group, Shasta Ventures, and accounts managed by T. Rowe Price Associates. The new round brings the total raised to $136 million.

CB Insights took at look at which seed deals received follow-on funding and listed investors by the ability of their portfolios to raise new money. Here are the top 10.

Despite the popularity of Facebook and Instagram, a growing number of smartphone users are clearly looking for alternative communications platforms. The question is whether such new apps are real businesses, or if they’re just as evanescent as the technology solutions they provide.

Ben Franklin Technology Partners Southeastern PA, a Philadelphia-based early-stage backer, invested $1.54 million in 11 deals during March, ranking it as the most active investor in the month. Draper Fisher Jurvetson was the most active institutional venture firm in the month, having backed seven companies with nearly $9 million, according to Thomson Reuters data.

Mountain View, Calif.-based Instart Logic has emerged from stealth, announcing a $17 million Series B round. The funding brings the total amount raised by the company to $26 million, which the company is using to create a cloud-based solution to help mobile Web apps operate quicker. Investors include Andreessen Horowitz, Greylock Partners, Sutter Hill Ventures and Tenaya Capital, as well as individual investors from Silicon Valley.

Private company valuations for security companies are up, but venture investors remain excited about putting to money to work. There is no secret why. Governments and corporations are under attack from cyber hacks, and IT budgets are being freed up for products and services to strengthened digital defenses.

This week there are plenty of junior positions for those looking to make a start in the industry ranging from summer interns to analyst positions as well as a couple of more senior positions at Riverside Associates and H.I.G. Capital.

Domo, a new software-as-a-service venture launched by Omniture co-founder Josh James has raised $60 million in Series B financing. GGV Capital, Greylock Partners, Bezos Expeditions, the personal investment company of Jeff Bezos, Workday co-CEOs Aneel Bhusri and David Duffield, Founders Fund and Mercato Partners, amongst others, invested in this round.

Electronic medical records management company Practice Fusion has made its first acquisition, scooping up 100Plus for an undisclosed amount. 100Plus, which was launched in Practice Fusion’s health tech incubator in San Francisco, previously raised $1.25 million in seed-stage funding from Founders Fund (which is also a Practice Fusion investor), Greylock Discovery Fund, Felicis Ventures (another Practice Fusion investor) and the Band of Angels. 100Plus was co-founded by CEO Chris Hogg, a health care data analytics expert formerly with Gilead Sciences, who will join Practice Fusion’s data and product development group.

Agari has announced a $5 million strategic investment and the addition of two new executives. An undisclosed strategic investor and existing investors Alloy Ventures, Battery Ventures, First Round Capital and Greylock Partners participated in the round. Ingrum Putz has joined the company as vice president of engineering and Vidur Apparao as chief technology officer.