Expression Genetics Inc., a Huntsville, Ala.-based developer of DNA and RNAi delivery and therapeutics, has raised $12 million in Series B funding. No investor information was disclosed.
Expression Genetics, Inc., announced today that it has successfully completed its $12-million Series B financing. The final portion ($7M) of the financing was secured in July. The company plans to use this most recent funding to continue clinical development of its lead product EGEN-001, a cancer therapeutic, and to further advance its development of delivery technologies for siRNA and shRNA.
EGEN-001 is under development for the treatment of advanced recurrent ovarian cancer as well as other local or disseminated solid tumors. The product is based on proprietary TheraPlas(R) delivery technology. It is composed of an interleukin-12 (IL-12) gene expression plasmid and a biocompatible delivery polymer. IL-12 is a potent cytokine which works by multiple mechanisms of action to enhance the body's immune system against cancer and inhibit tumor blood supply. EGEN-001 has completed a Phase I monotherapy trial with promising results and is currently in the final stage of a Phase IA trial designed to evaluate safety and preliminary efficacy of the drug when administered in combination with conventional chemotherapy treatment. EGEN-001 received Orphan Drug Status from the FDA in 2005 and a $1 million FDA Orphan Grant in 2007.
The company is developing its proprietary TheraSilence(TM) delivery technology for RNAi therapeutics. Novel molecules, especially designed to deliver RNAi to cells, are being developed in company laboratories. Gene knock down in vitro and in vivo in animal models has been demonstrated and candidate systems targeting specific diseases are being screened for preclinical development.
“Successful completion of this financing was largely due to recognition and appreciation of our exciting progress in both the EGEN-001 human clinical trials and our research advances on RNAi delivery technology. We are pleased and grateful for this support,” commented Dr. Danny H. Lewis, CEO of Expression Genetics. “This will allow us to expedite the overall clinical program for EGEN-001 and enable us to continue development of the promising technologies for delivery of therapeutic RNAi.” Participation in the round was by VC and private investors.
About Expression Genetics, Inc.
Expression Genetics, Inc. (EGEN), is a privately held biopharmaceutical company specializing in nucleic acid (DNA and RNAi) delivery and therapeutics aimed at specific disease targets. The Company, with laboratories and headquarters in