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Aeglea Biotherapeutics snags $44 mln Series B

Aeglea Biotherapeutics Inc, a biopharmaceutical company focused on treating tumor metabolism, has raised $44 million in Series B funding. Return backers Lilly Ventures and Novartis Venture Fund led the round with participation from other investors that included UT Horizon Fund, OrbiMed, Jennison Associates (on behalf of clients), Venrock, RA Capital Management, Rock Springs Capital, Ally Bridge Group and Cowen Investments.

Foresite Capital leads Series B round for Allergen Research Corp

San Mateo, California-based Allergen Research Corp, which develops treatments for food allergies, has closed $80 million in Series B funding. Foresite Capital led the round with participation from Longitude Capital, Fidelity Management & Research Company, Aisling Capital, Adage Capital, RA Capital Management and Palo Alto Investors. In conjunction with the funding, Dr. Jim Tananbaum, CEO and managing director of Foresite Capital and Stacey Seltzer, a partner at Aisling Capital, have been added to ARC’s board of directors.

Collegium Pharmaceutical grabs $50 mln

Canton, Massachusetts-based Collegium Pharmaceutical Inc, a specialty pharmaceutical company focused on treating chronic pain, has secured $50 million in funding. TPG Biotech led the round with participation from RA Capital Management, Adage Capital Management, Rock Springs Capital, EcoR1 Capital, Eventide Asset Management, Aperture Venture Partners, Longitude Capital, Skyline Ventures, Frazier Healthcare and Boston Millennia Partners. In conjunction with this financing, Dr. Eran Nadav, a partner and managing director at TPG Biotech, has been added to Collegium’s board of directors.

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WaVE Lifes Sciences pulls in $18 mln

Boston and Japan-based WaVe Life Sciences, a provider of nucleic acid therapeutics, has raised $18 million in Series A funding. RA Capital Management LLC and Kagoshima Shinsangyo Sosei Investment LP led the round with participation from founding investor SNBL Ltd. In addition to the financing, Dr. Peter Kolchinsky, a managing general partner of RA Capital, has been added to WaVe’s board of directors.

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VC-backed Ascendis Pharma goes public

Danish biotech firm Ascendis Pharma has raised $108 million for its IPO after pricing its 6 million shares at $18 per share. The stock begins trading Wednesday on the NASDAQ under the ticker symbol “ASND.” BofA Merrill Lynch and Leerink Partners are serving as the lead underwriters. Ascendis Pharma’s backers include Sofinnova Ventures, OrbiMed, Vivo Capital, Venrock, RA Capital Management and Janus Capital Management.

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Cortendo to raise up to $27.5 mln in private placement

Cortendo AB has agreed to receive up to $27.5 million in a private placement. The investors are RA Capital Management, New Enterprise Associates, Broadfin Capital and HealthCap. Headquartered in Göteborg, Sweden and with offices in Radnor, Pennsylvania, Cortendo is a biopharmaceutical firm focused on orphan endocrine disorders.

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Moderna Therapeutics scores $450 mln

Cambridge Mass.-based biotech firm Moderna Therapeutics has closed $450 million in funding. The backers in this round include Viking Global Investors, Invus, RA Capital Management, Wellington Management Company, AstraZeneca and Alexion Pharmaceuticals.

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Sofinnova Ventures, OrbiMed, Vivo Capital lead $60 mln funding in Ascendis Pharma

Sofinnova Ventures, OrbiMed and Vivo Capital have led a $60 million Series D funding in Ascendis Pharma, a biotechnology company. Other investors in the funding include Janus Capital Management, Venrock, RA Capital Management, Rock Springs Capital and Sectoral Asset Management. Ascendis Pharma’s largest shareholder, Sofinnova Partners, also participated in the funding round. James Healy of Sofinnova Ventures, Jonathan Silverstein of OrbiMed and Albert Cha of Vivo Capital have joined the company’s board of directors.

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ZipLine Medical nabs $5.7 mln Series C

ZipLine Medical has raised $5.7 million in Series C financing. China Materialia led the round with participation from return backers RA Capital Management, Claremont Creek Ventures and XSeed Capital. According to the firm, the capital will be used to expand its sales and marketing efforts. In addition to the funding, Dr. Min Zhou, CEO of China Materialia, has been added to ZipLine’s board of directors. Based in Campbell, Calif., ZipLine Medical is a medical device company.

Coherus BioSciences nabs $55 mln Series C

Coherus BioSciences has raised $55 million in Series C funding. The investors included KKR, Venrock, RA Capital Management, Rock Springs Capital, Fidelity Biosciences, Sofinnova Ventures, Lilly Ventures and Vivo Capital. Based in Redwood City, Calif., Coherus BioSciences is a biologics platform focused on biosimilars.

Shire acquires VC-backed Lumena Pharmaceuticals

Shire has acquired Lumena Pharmaceuticals. No financial terms were disclosed. Citi provided financial advice to Lumena. Based in San Diego, Lumena is a biopharmaceutical company focused on rare cholestatic liver diseases and serious metabolic disorders. Its backers include New Enterprise Associates, Adage Capital Management, RA Capital Management, Pappas Ventures, RiverVest Venture Partners and Alta Partners.

ProNAi Therapeutics raises Series D

ProNAi Therapeutics, a developer of novel nucleic acid therapeutics has closed an oversubscribed $59.5 million Series D financing. The round was led by Vivo Capital and included other new investors Frazier Healthcare Ventures, OrbiMed Advisors, Adams Street Partners, RA Capital Management, Caxton Alternative Management, Hopen Life Science Ventures, Sectoral Asset Management and Janus Capital Management.

VC-backed Zafgen nabs $20 mln from Oxford and MidCap Financial

Zafgen has secured a $20 million loan from Oxford and MidCap Financial. Based in Cambridge, Mass., Zafgen is a biopharmaceutical company focused on treating severely obese patients. Zafgen’s investors include RA Capital Management, Brookside Capital, Venrock and Alta Partners.

Lumena attracts $45 mln in Series B funds

Lumena Pharmaceuticals said Tuesday that it has closed $45 million in Series B financing. New Enterprise Associates led the round with participation from Adage Capital Management, RA Capital Management, Pappas Ventures, RiverVest Venture Partners and Alta Partners. Based in San Diego, Lumena is a biopharmaceutical company focused on rare cholestatic liver diseases and serious metabolic disorders.

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